Purpose: Resistance to platinum chemotherapy remains a significant problem in ovarian carcinoma.

Early studies showed antitumor activity, especially against malignant melanoma and ovarian carcinoma.

Six of these genes were not previously implicated in inherited ovarian carcinoma.

However, its clinical significance in human ovarian carcinoma has been uncertain until recently.

Distant metastases are unusual at presentation and during the course of ovarian carcinoma.